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SCIENTIFIC SCORE
Moderately Effective
Based on 4 Researches
8
USERS' SCORE
Good
Based on 2 Reviews
8.6
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Zinc(from 270 mg Zinc Picolinate)
50 mg
455%
Top Medical Research Studies
8
Zinc's role in lung cancer treatment
The human zinc-binding cysteine proteome.
Investigates zinc and cancer relationship
We explored the role of zinc as an essential micronutrient that influences various physiological processes, particularly in the context of lung cancer. Our study focused on understanding how zinc binds to specific sites on proteins, especially cysteine residues, and how this binding affects cancer cell behavior.
Through a thorough mapping called ZnCPT, we identified a significant number of zinc-binding cysteines—6,173 in total. This mapping allowed us to uncover several protein families that are affected by zinc binding, either on a regular basis or when induced.
Importantly, we discovered that zinc could influence 52 genetic dependencies in cancer, pointing toward some malignancies that might be particularly sensitive to zinc's effects. In our findings, we observed a specific mechanism where zinc regulates the enzyme glutathione reductase (GSR). This regulation appears to drive cell death in certain lung cancers that rely on GSR, suggesting a potential avenue for future treatments.
Overall, while zinc shows promise in affecting lung cancer cells, further investigation will be essential to fully understand its therapeutic potential.
Through a thorough mapping called ZnCPT, we identified a significant number of zinc-binding cysteines—6,173 in total. This mapping allowed us to uncover several protein families that are affected by zinc binding, either on a regular basis or when induced.
Importantly, we discovered that zinc could influence 52 genetic dependencies in cancer, pointing toward some malignancies that might be particularly sensitive to zinc's effects. In our findings, we observed a specific mechanism where zinc regulates the enzyme glutathione reductase (GSR). This regulation appears to drive cell death in certain lung cancers that rely on GSR, suggesting a potential avenue for future treatments.
Overall, while zinc shows promise in affecting lung cancer cells, further investigation will be essential to fully understand its therapeutic potential.
Read More
8
Zinc complex shows lung cancer potential
Syntheses, structures and anti-cancer activities of Cu and Zn complexes containing 1,1'-[(3-fluoro-phen-yl)methyl-ene]bis-[3-(3-fluoro-phen-yl)imidazo[1,5-]pyridine].
Moderate relevance in zinc effects
We synthesized two new metal complexes involving zinc and copper, linked to a specific compound. The goal was to assess how these complexes might impact lung cancer cells, specifically focusing on their anti-cancer activities compared to a free ligand.
Our exploration revealed that the zinc complex showed promising effectiveness against the A549 lung cancer cell line. The results indicated that its inhibitory concentration (IC) values ranged from 18.93 to 24.83 µM, which highlights its capability in fighting lung cancer. While it’s significant, we also noted that the zinc complex was evaluated alongside a copper complex, making it difficult to isolate the effects of zinc alone.
The effectiveness of both complexes presents meaningful avenues for cancer treatment. Given the promising results with zinc, further investigations could clarify its potential in clinical applications against lung cancer and beyond.
Our exploration revealed that the zinc complex showed promising effectiveness against the A549 lung cancer cell line. The results indicated that its inhibitory concentration (IC) values ranged from 18.93 to 24.83 µM, which highlights its capability in fighting lung cancer. While it’s significant, we also noted that the zinc complex was evaluated alongside a copper complex, making it difficult to isolate the effects of zinc alone.
The effectiveness of both complexes presents meaningful avenues for cancer treatment. Given the promising results with zinc, further investigations could clarify its potential in clinical applications against lung cancer and beyond.
Read More
7
Investigation of zinc in lung cancer
A Polymeric Vesicle System for Combined Lung Cancer Therapy through Chemotherapy and Vasculature Normalization.
Mixed treatment effectiveness evaluated
We explored a unique strategy for treating lung cancer that combines chemotherapy with an innovative approach to normalizing tumor blood vessels. Our focus was on a nanosystem that not only delivers the chemotherapy drug paclitaxel (PTX) but also incorporates zinc oxide nanoparticles (ZnO NPs) and a nitric oxide (NO) precursor, allowing us to observe how these components work together in a cancer-fighting capacity.
In our approach, the nanosystem releases zinc ions at the acidic pH typical of the tumor environment, aiming to enhance the drug's effectiveness. The added benefit of generating nitric oxide further helps in reducing the blood flow to tumors, potentially improving the distribution and uptake of chemotherapy.
While we saw promising results regarding the combined therapy with paclitaxel and the effect of zinc, it is necessary to note that isolated effects of zinc on lung cancer treatment couldn't be clearly established in this study. Therefore, while there’s potential worth investigating further, we cannot definitively conclude that zinc alone acts as a significant treatment option.
In our approach, the nanosystem releases zinc ions at the acidic pH typical of the tumor environment, aiming to enhance the drug's effectiveness. The added benefit of generating nitric oxide further helps in reducing the blood flow to tumors, potentially improving the distribution and uptake of chemotherapy.
While we saw promising results regarding the combined therapy with paclitaxel and the effect of zinc, it is necessary to note that isolated effects of zinc on lung cancer treatment couldn't be clearly established in this study. Therefore, while there’s potential worth investigating further, we cannot definitively conclude that zinc alone acts as a significant treatment option.
Read More
Most Useful Reviews
8.8
Effective treatment
Excellent! I chose this form of zinc for its effectiveness. After recovering from coronavirus, I took it with D3, B vitamins, and selenium. I quickly regained strength, my hair stopped falling out, and I felt less weak, despite having had 46% lung damage. I highly recommend it.
Read More
8.8
Lung recovery support
Excellent zinc in the right form! I took it after Covid for three weeks as it’s beneficial for lung recovery post-pneumonia. My hair became fuller, and my eyelashes grew long and fluffy. I recommend this; it truly works.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 4 Researches
8
9
Zinc's role in lung cancer treatment
Zinc-based radioenhancers to activate tumor radioimmunotherapy by PD-L1 and cGAS-STING pathway.
Combined effects limit isolated assessment
We investigated a cutting-edge approach that uses zinc-based compounds alongside other treatments to enhance the effects of radiotherapy in lung cancer, specifically non-small-cell lung cancer (NSCLC). The study introduced a radio-immuno-enhancer known as ZnO-Au@mSiO, which plays a dual role as a radiosensitizer and an immune activator.
This innovative enhancer not only targets and induces the death of cancer cells through radiation but also aims to invigorate the immune system. We observed that the combined effects of zinc with gold nanoparticles help bring "exhausted" T cells back into action by promoting immunogenic cell death and targeting immune checkpoints like PD-1 and PD-L1.
Importantly, results demonstrated that using this radio-immuno-enhancer led to a significant increase in protective immune responses, especially the levels of cytotoxic T cells and helper T cells. However, it's crucial to note that while zinc was a component of this treatment strategy, it was evaluated in conjunction with other agents, making it difficult to assess its standalone effectiveness for lung cancer.
This innovative enhancer not only targets and induces the death of cancer cells through radiation but also aims to invigorate the immune system. We observed that the combined effects of zinc with gold nanoparticles help bring "exhausted" T cells back into action by promoting immunogenic cell death and targeting immune checkpoints like PD-1 and PD-L1.
Importantly, results demonstrated that using this radio-immuno-enhancer led to a significant increase in protective immune responses, especially the levels of cytotoxic T cells and helper T cells. However, it's crucial to note that while zinc was a component of this treatment strategy, it was evaluated in conjunction with other agents, making it difficult to assess its standalone effectiveness for lung cancer.
Read More
8
Zinc complex shows lung cancer potential
Syntheses, structures and anti-cancer activities of Cu and Zn complexes containing 1,1'-[(3-fluoro-phen-yl)methyl-ene]bis-[3-(3-fluoro-phen-yl)imidazo[1,5-]pyridine].
Moderate relevance in zinc effects
We synthesized two new metal complexes involving zinc and copper, linked to a specific compound. The goal was to assess how these complexes might impact lung cancer cells, specifically focusing on their anti-cancer activities compared to a free ligand.
Our exploration revealed that the zinc complex showed promising effectiveness against the A549 lung cancer cell line. The results indicated that its inhibitory concentration (IC) values ranged from 18.93 to 24.83 µM, which highlights its capability in fighting lung cancer. While it’s significant, we also noted that the zinc complex was evaluated alongside a copper complex, making it difficult to isolate the effects of zinc alone.
The effectiveness of both complexes presents meaningful avenues for cancer treatment. Given the promising results with zinc, further investigations could clarify its potential in clinical applications against lung cancer and beyond.
Our exploration revealed that the zinc complex showed promising effectiveness against the A549 lung cancer cell line. The results indicated that its inhibitory concentration (IC) values ranged from 18.93 to 24.83 µM, which highlights its capability in fighting lung cancer. While it’s significant, we also noted that the zinc complex was evaluated alongside a copper complex, making it difficult to isolate the effects of zinc alone.
The effectiveness of both complexes presents meaningful avenues for cancer treatment. Given the promising results with zinc, further investigations could clarify its potential in clinical applications against lung cancer and beyond.
Read More
8
Zinc's role in lung cancer treatment
The human zinc-binding cysteine proteome.
Investigates zinc and cancer relationship
We explored the role of zinc as an essential micronutrient that influences various physiological processes, particularly in the context of lung cancer. Our study focused on understanding how zinc binds to specific sites on proteins, especially cysteine residues, and how this binding affects cancer cell behavior.
Through a thorough mapping called ZnCPT, we identified a significant number of zinc-binding cysteines—6,173 in total. This mapping allowed us to uncover several protein families that are affected by zinc binding, either on a regular basis or when induced.
Importantly, we discovered that zinc could influence 52 genetic dependencies in cancer, pointing toward some malignancies that might be particularly sensitive to zinc's effects. In our findings, we observed a specific mechanism where zinc regulates the enzyme glutathione reductase (GSR). This regulation appears to drive cell death in certain lung cancers that rely on GSR, suggesting a potential avenue for future treatments.
Overall, while zinc shows promise in affecting lung cancer cells, further investigation will be essential to fully understand its therapeutic potential.
Through a thorough mapping called ZnCPT, we identified a significant number of zinc-binding cysteines—6,173 in total. This mapping allowed us to uncover several protein families that are affected by zinc binding, either on a regular basis or when induced.
Importantly, we discovered that zinc could influence 52 genetic dependencies in cancer, pointing toward some malignancies that might be particularly sensitive to zinc's effects. In our findings, we observed a specific mechanism where zinc regulates the enzyme glutathione reductase (GSR). This regulation appears to drive cell death in certain lung cancers that rely on GSR, suggesting a potential avenue for future treatments.
Overall, while zinc shows promise in affecting lung cancer cells, further investigation will be essential to fully understand its therapeutic potential.
Read More
7
Investigation of zinc in lung cancer
A Polymeric Vesicle System for Combined Lung Cancer Therapy through Chemotherapy and Vasculature Normalization.
Mixed treatment effectiveness evaluated
We explored a unique strategy for treating lung cancer that combines chemotherapy with an innovative approach to normalizing tumor blood vessels. Our focus was on a nanosystem that not only delivers the chemotherapy drug paclitaxel (PTX) but also incorporates zinc oxide nanoparticles (ZnO NPs) and a nitric oxide (NO) precursor, allowing us to observe how these components work together in a cancer-fighting capacity.
In our approach, the nanosystem releases zinc ions at the acidic pH typical of the tumor environment, aiming to enhance the drug's effectiveness. The added benefit of generating nitric oxide further helps in reducing the blood flow to tumors, potentially improving the distribution and uptake of chemotherapy.
While we saw promising results regarding the combined therapy with paclitaxel and the effect of zinc, it is necessary to note that isolated effects of zinc on lung cancer treatment couldn't be clearly established in this study. Therefore, while there’s potential worth investigating further, we cannot definitively conclude that zinc alone acts as a significant treatment option.
In our approach, the nanosystem releases zinc ions at the acidic pH typical of the tumor environment, aiming to enhance the drug's effectiveness. The added benefit of generating nitric oxide further helps in reducing the blood flow to tumors, potentially improving the distribution and uptake of chemotherapy.
While we saw promising results regarding the combined therapy with paclitaxel and the effect of zinc, it is necessary to note that isolated effects of zinc on lung cancer treatment couldn't be clearly established in this study. Therefore, while there’s potential worth investigating further, we cannot definitively conclude that zinc alone acts as a significant treatment option.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.6
8.8
Effective treatment
Excellent! I chose this form of zinc for its effectiveness. After recovering from coronavirus, I took it with D3, B vitamins, and selenium. I quickly regained strength, my hair stopped falling out, and I felt less weak, despite having had 46% lung damage. I highly recommend it.
8.8
Lung recovery support
Excellent zinc in the right form! I took it after Covid for three weeks as it’s beneficial for lung recovery post-pneumonia. My hair became fuller, and my eyelashes grew long and fluffy. I recommend this; it truly works.
